The San Francisco 49ers made a couple of roster moves Wednesday ahead of their Thursday night matchup with the Seattle ...

San Francisco 49ers running back Christian McCaffrey won't return in Week 6, but will likely make his long-awaited comeback ...

San Francisco 49ers star Christian McCaffrey could return as soon as Week 7, according to a report from ESPN's Adam Schefter.

After two plays, the San Francisco 49ers leading receiver exited Sunday’s Week 5 game with an apparent injury. After opening ...

San Francisco 49ers linebacker Fred Warner will play Sunday. His status was in question for Week 5 against the Arizona ...

San Francisco 49ers' stars George Kittle and Fred Warner are dealing with injuries, and here is the latest on their playing ...

The San Francisco 49ers' political spending spree in Santa Clara, home of Levi's Stadium, is back in full force.

Talanoa Hufanga is likely to end up on Injured Reserve soon. He suffered torn ligaments in his wrist in the San Francisco ...

After Sunday’s bizarre come-from-ahead loss to the Cardinals, star defensive end Nick Bosa said the 49ers needed to get back ...

The Tennessee Titans could be sellers at the NFL trade deadline after a 1-3 start, and with the San Francisco 49ers having a ...

The 49ers aren't playing to Brock Purdy's strengths this season. He's an elite play-action passer. He can turn his back to the defense, fake a ha ...

San Francisco 49ers head coach Kyle Shanahan says he texted former New York Jets head coach Robert Saleh after receiving the ...